Chyloperitoneum, chylothorax and lower extremity lymphedema in woman with sporadic lymphangioleiomyomatosis successfully treated with sirolimus: a case report.
Identifieur interne : 004450 ( Main/Exploration ); précédent : 004449; suivant : 004451Chyloperitoneum, chylothorax and lower extremity lymphedema in woman with sporadic lymphangioleiomyomatosis successfully treated with sirolimus: a case report.
Auteurs : A. Chachaj [Pologne] ; K. Drozdz ; M. Chabowski ; P. Dziegiel ; I. Grzegorek ; A. Wojnar ; P. Jazwiec ; A. SzubaSource :
- Lymphology [ 0024-7766 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Ascite chyleuse (diagnostic), Ascite chyleuse (traitement médicamenteux), Chylothorax (diagnostic), Chylothorax (traitement médicamenteux), Femelle, Humains, Immunosuppresseurs (usage thérapeutique), Jambe, Lymphangioléiomyomatose (traitement médicamenteux), Lymphoedème (diagnostic), Lymphoedème (traitement médicamenteux), Pronostic, Sirolimus (usage thérapeutique), Tomodensitométrie.
- MESH :
- diagnostic : Ascite chyleuse, Chylothorax, Lymphoedème.
- traitement médicamenteux : Ascite chyleuse, Chylothorax, Lymphangioléiomyomatose, Lymphoedème.
- usage thérapeutique : Immunosuppresseurs, Sirolimus.
- Adulte d'âge moyen, Femelle, Humains, Jambe, Pronostic, Tomodensitométrie.
English descriptors
- KwdEn :
- Chylothorax (diagnosis), Chylothorax (drug therapy), Chylous Ascites (diagnosis), Chylous Ascites (drug therapy), Female, Humans, Immunosuppressive Agents (therapeutic use), Leg, Lymphangioleiomyomatosis (drug therapy), Lymphedema (diagnosis), Lymphedema (drug therapy), Middle Aged, Prognosis, Sirolimus (therapeutic use), Tomography, X-Ray Computed.
- MESH :
- chemical , therapeutic use : Immunosuppressive Agents, Sirolimus.
- diagnosis : Chylothorax, Chylous Ascites, Lymphedema.
- drug therapy : Chylothorax, Chylous Ascites, Lymphangioleiomyomatosis, Lymphedema.
- Female, Humans, Leg, Middle Aged, Prognosis, Tomography, X-Ray Computed.
Abstract
Lymphangioleiomyomatosis (LAM) is a rare disease characterized by diffuse thin-walled cysts throughout the lungs on computed tomography and diffuse proliferation of abnormal smooth muscle-like cells (LAM cells) on lung biopsy. LAM affects women almost exclusively, predominantly in their reproductive age. The most typical presenting symptoms include dyspnea, spontaneous pneumothorax, cough and chylothorax. Abdominal findings represent less common initial manifestations of the disease and may pose diagnostic difficulties. The treatment of LAM has not been fully established. Recent studies report effectiveness of sirolimus in LAM patients. We report the case of a 45-year-old woman with sporadic LAM, successfully treated with sirolimus, in whom the first manifestation of the disease was chyloperitoneum and after three and nine years, respectively, lymphedema of the left lower extremity and right sided chylothorax occurred.
PubMed: 23057149
Affiliations:
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<term>Chylous Ascites (diagnosis)</term>
<term>Chylous Ascites (drug therapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunosuppressive Agents (therapeutic use)</term>
<term>Leg</term>
<term>Lymphangioleiomyomatosis (drug therapy)</term>
<term>Lymphedema (diagnosis)</term>
<term>Lymphedema (drug therapy)</term>
<term>Middle Aged</term>
<term>Prognosis</term>
<term>Sirolimus (therapeutic use)</term>
<term>Tomography, X-Ray Computed</term>
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<term>Ascite chyleuse (traitement médicamenteux)</term>
<term>Chylothorax (diagnostic)</term>
<term>Chylothorax (traitement médicamenteux)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunosuppresseurs (usage thérapeutique)</term>
<term>Jambe</term>
<term>Lymphangioléiomyomatose (traitement médicamenteux)</term>
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<term>Lymphoedème (traitement médicamenteux)</term>
<term>Pronostic</term>
<term>Sirolimus (usage thérapeutique)</term>
<term>Tomodensitométrie</term>
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<term>Sirolimus</term>
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<term>Chylous Ascites</term>
<term>Lymphedema</term>
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<term>Lymphoedème</term>
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<term>Chylous Ascites</term>
<term>Lymphangioleiomyomatosis</term>
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<front><div type="abstract" xml:lang="en">Lymphangioleiomyomatosis (LAM) is a rare disease characterized by diffuse thin-walled cysts throughout the lungs on computed tomography and diffuse proliferation of abnormal smooth muscle-like cells (LAM cells) on lung biopsy. LAM affects women almost exclusively, predominantly in their reproductive age. The most typical presenting symptoms include dyspnea, spontaneous pneumothorax, cough and chylothorax. Abdominal findings represent less common initial manifestations of the disease and may pose diagnostic difficulties. The treatment of LAM has not been fully established. Recent studies report effectiveness of sirolimus in LAM patients. We report the case of a 45-year-old woman with sporadic LAM, successfully treated with sirolimus, in whom the first manifestation of the disease was chyloperitoneum and after three and nine years, respectively, lymphedema of the left lower extremity and right sided chylothorax occurred.</div>
</front>
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<name sortKey="Grzegorek, I" sort="Grzegorek, I" uniqKey="Grzegorek I" first="I" last="Grzegorek">I. Grzegorek</name>
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